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RpveScore

发布日期:2017-1-16 11:10:54      作者:      来源:

RpveScore

Overview
RpveScore is a software, providing an energy scoring function, referred toas RpveScore, for binding mode selection to study protein-RNA interactions. Protein-RNAdocking is still an open question. One of the main challenges is to develop aneffective scoring function that can discriminate near-native structures fromthe incorrect ones. To solve the problem, we have constructed a knowledge-basedresidue-nucleotide pairwise potential with secondary structureinformation considered for non-ribosomal protein-RNA docking.Here we developed a weighted combined scoring functionRpveScore that consists of the pairwise potential and sixphysics-based energyterms. RpveScore has been validated with unbounddocking test sets. The RpveScore software can be used stand-alone or easilyimplemented in other docking programs for protein-RNA recognition.


Availability
RpveScore isavailable free of charge for academic users. Toobtain an academic user license,pleasedownload the “RpveScore academic licensefile, fill out, and fax back to us. Then, you can download RpveScore upon approval.


References
ZhaoZhang, Lin Lu, Yue Zhang, Chun Hua Li,* Cun XinWang, Xiao Yi Zhang, and Jian Jun Tan. A combinatorial scoring functionfor protein-RNA docking.


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